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Valproic acid, MedChemExpress

Artikelnummer. 16496757
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Mængde:
1 g
5 g
25 g
Pakningsstørrelse:
25g
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Artikelnummer. 16496757 Leverandør Medchem Express Leverandørnr. HY10585

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MedChemExpress Valproic acid (VPA) is an orally active HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid is used in the treatment of epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches.

Valproic acid (VPA) is an orally active HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid is used in the treatment of epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches.

Tekniske data

Kemisk navn eller materiale Valproic acid
Fysisk form Liquid
CAS 99-66-1
Farve Light Yellow
Mængde 5 g
Renhedsgrad noter Research
Molekylær formel C8H16O2
Til brug med (applikation) Cancer-Kinase/protease
Synonym VPA 2-Propylpentanoic Acid
Opløselighedsinformation DMSO : 100 mg/mL (693.43 mM; Need ultrasonic) ∣H2O : 1 mg/mL (6.93 mM; Need ultrasonic and warming)
SMIL CCCC(CCC)C(O)=O
Molekylvægt (g/mol) 144.21
Formel vægt 144.21
Procent renhed 98.0%
Grad Research
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Research purposes only

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