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Tocris Bioscience™ UNC 8732

Artikelnummer. 30058541
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Mængde:
5 mg
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30058541 5 mg
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Artikelnummer. 30058541 Leverandør Tocris Bioscience™ Leverandørnr. 8118/5

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Beskrivelse

Potent NSD2 Degrader

UNC 8732 is a potent nuclear receptor binding SET domain-containing 2 (NSD2) Degrader (DC50 = 60 nM; Dmax = 97%). NSD2 degradation is driven by the aldehyde metabolite of UNC 8732 in vitro. Recruits FBX022 and SCF complexes for degradation to reduce H3K36me2 levels in cells. Reduces viability and restores glucocorticoid sensitivity of NSD2 p.E1099K mutant ALL cells.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale N-[[4-[[[2-(6-Amino-1-oxohexyl)-1,2,3,4-tetrahydro-6-isoquinolinyl]amino]carbonyl]phenyl]methyl]-N-cyclopropyl-3,4-dihydro-3-oxo-2H-1,4-benzoxazine-7-carboxamide trifluoroacetate
CAS 2929304-06-1
Mængde 5 mg
Mål Active Degraders
Molekylær formel C35H39N5O5.CF3CO2H
Renhed 0.98
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