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ULBP1 Monoclonal Antibody (3A6F11), Invitrogen™
Mouse Monoclonal Antibody
Brand: Thermo Scientific MA538655
This item is not returnable.
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Description
This antibody has been tested in indirect ELISA.
ULBP1 is the ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.
Specifications
| ULBP1 | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 0.05% sodium azide | |
| Q9BZM6 | |
| ULBP1 | |
| Purified recombinant fragment of human ULBP1 (aa: 26-216) expressed in E. Coli. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
| Flow Cytometry, Western Blot | |
| 3A6F11 | |
| Unconjugated | |
| ULBP1 | |
| A430108B07Rik; ALCAN-beta; MULT1; N2DL1; N2DL-1; NKG2D ligand; NKG2D ligand 1; NKG2D ligand1; NKG2DL1; RAET1I; retinoic acid early transcript 1I; UL16 binding protein 1; UL16-binding protein 1; UL16-binding protein-like transcript 1; ULBP; ULBP 1; ULBP1 | |
| Mouse | |
| Protein G | |
| RUO | |
| 80329 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
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Product Title
ULBP1 Monoclonal Antibody (3A6F11), Invitrogen™ > 100 μg; Unconjugated
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