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STEMCELL Technologies TWS119

Artikelnummer. 17180232
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Mængde:
1 mg
10 mg
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17180232 10 mg
17170232 1 mg
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Artikelnummer. 17180232 Leverandør STEMCELL Technologies Leverandørnr. 73514

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Beskrivelse

WNT pathway activator; Inhibits GSK3β

  • TWS119 is a potent disubstituted pyrrolopyrimidine inhibitor of glycogen synthase kinase 3 beta (GSK3β) with an IC50 of 30 nM and Kd of 126 nM (Ding et al.) GSK3 is a serine/threonine kinase that is a key inhibitor of the WNT pathway; therefore TWS119 functions as a WNT pathway activator
  • Maintains the bi-potent, quiescent state in hepatic stellate cells of Wistar rats (Kordes et al.)
  • Induces differentiation of mouse embryonal carcinoma and embryonic stem cells to neurons (Ding et al.)
  • Induces production of T memory stem cell-like (T-SCM) cells from mouse or human CD8+ T cells with evidence of increased persistence, proliferation, and anti-tumor activity after adoptive transfer of mouse-derived T-SCM (Forget et al.; Gattinoni et al.)
  • Inhibits cell proliferation and induces apoptosis in human alveolar rhabdomyosarcoma cells (Zeng et al.)

Tekniske data

CAS 601514-19-6
Synonym GSK 3B Inhibitor XII
Mængde 10 mg
Molekylær formel C18H14N4O2
Renhed ≥90%
Produkttitel
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