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Tocris Bioscience™ tri-GalNAc-C5-amine

Artikelnummer. 18769426
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1 mg
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18769426 1 mg
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Artikelnummer. 18769426 Leverandør Tocris Bioscience™ Leverandørnr. 7781/1

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Beskrivelse

Asialoglycoprotein receptor ligand with alkylC5 linker and amine group for onward chemistry

tri-GalNAc-C5-amine is a functionalized asialoglycoprotein receptor (ASGPR) ligand for lysosomal targeting chimera (LYTAC) research and development; each molecule incorporates three ASGPR ligands with an alkylC5 linker and an amine group reactive handle ready for conjugation. Upon binding to the ASGPR, tri-GalNAc conjugates are efficiently internalized via ASGPR-mediated endocytosis. tri-GalNAc conjugation can be employed as a strategy to effectively deliver cargo such as RNA or Cas9 complexes in a cell-specific manner to hepatocytes. Can be used to generate LYTACs, or labeled with dye for tissue imaging.
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Tekniske data

Kemisk navn eller materiale N-[2-[[1-[2-[2-[2-[2-[[2-(Acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methoxy]-1,1-bis[[[1-[2-[2-[2-[2-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-tr
CAS 2098275-86-4
Mængde 1 mg
Mål ASGPR1
Molekylær formel C67H118N14O31
Produkttitel
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