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Tocris Bioscience™ TM2 TEAD inhibitor

Potent and reversible inhibitor of TEAD mediated Hippo/Yap signalling

1170.00 DKK - 4380.00 DKK

Specifications

Chemical Name or Material 4-[3-(2-Cyclohexylethoxy)benzoyl]-N-phenyl-1-piperazinecarboxamide
CAS 1008768-41-9
Target YAP1
Molecular Formula C26H33N3O3
Purity 0.98
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
18706075
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Tocris Bioscience™
7917/10
10 mg
1170.00 DKK
10mg
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18705925
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Tocris Bioscience™
7917/50
50 mg
4380.00 DKK
50mg
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Description

Description

TM2 TEAD inhibitor is a potent and reversible TEA domain transcription factor inhibitor (IC50 = 38 nM and 156 nM for TEAD4 auto-palmitoylation and TEAD2 palmitoylation, respectively). It inhibits TEAD-YAP association and transcriptional activity. TM2 TEAD inhibitor exhibits strong antiproliferation effects as a single agent or in combination with a MEK inhibitor in YAP-dependent cancer cells. Also inhibits YAP-dependent liver organoid growth ex vivo.
Specifications

Specifications

4-[3-(2-Cyclohexylethoxy)benzoyl]-N-phenyl-1-piperazinecarboxamide
YAP1
0.98
1008768-41-9
C26H33N3O3
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Safety and Handling

Safety and Handling

Recommended Storage : Store at -20°C

SDS
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Documents

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