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  5. Tocris Bioscience™ TM2 TEAD inhibitor

Tocris Bioscience™ TM2 TEAD inhibitor
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Artikelnummer. 18706075
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Mængde:
10 mg
50 mg
Denne vare kan ikke returneres. Se returpolicy

Artikelnummer. 18706075

Brand: Tocris Bioscience™ 7917/10

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Beskrivelse

Potent and reversible inhibitor of TEAD mediated Hippo/Yap signalling

TM2 TEAD inhibitor is a potent and reversible TEA domain transcription factor inhibitor (IC50 = 38 nM and 156 nM for TEAD4 auto-palmitoylation and TEAD2 palmitoylation, respectively). It inhibits TEAD-YAP association and transcriptional activity. TM2 TEAD inhibitor exhibits strong antiproliferation effects as a single agent or in combination with a MEK inhibitor in YAP-dependent cancer cells. Also inhibits YAP-dependent liver organoid growth ex vivo.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale 4-[3-(2-Cyclohexylethoxy)benzoyl]-N-phenyl-1-piperazinecarboxamide
CAS 1008768-41-9
Mængde 10 mg
Mål YAP1
Molekylær formel C26H33N3O3
Renhed 0.98
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