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Tocris Bioscience™ TL 13-12
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Artikelnummer. 18706246
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5 mg
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18706246 5 mg
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Artikelnummer. 18706246 Leverandør Tocris Bioscience™ Leverandørnr. 6744/5

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Beskrivelse

Selective ALK Degrader (PROTAC™)

Selective anaplastic lymphoma kinase (ALK) degrader (DC50 values are 10 and 180 nM in H3122 and Karpas 299 cells, respectively). Comprises the cereblon E3 ligase ligand Pomalidomide (Cat. No. 6302), conjugated to an ALK inhibitor. Inhibits proliferation of ALK-positive cancer cell lines. Exhibits higher selectivity for ALK over Aurora A kinase compared with TL 13 -112 (Cat.No. 6745). Maximum degradation is exhibited at 16 h.

Negative control TL 13-22 (Cat. No. 6747) also available.

TL 13-12 is a selective anaplastic lymphoma kinase (ALK) Degrader (PROTAC®) (DC50 values are 10 and 180 nM in H3122 and Karpas 299 cells, respectively). Comprises the cereblon E3 ligase ligand Pomalidomide (Cat. No. 6302), conjugated to an ALK inhibitor. Inhibits proliferation of ALK-positive cancer cell lines. Exhibits higher selectivity for ALK over Aurora A kinase compared with TL 13 -112 (Cat.No. 6745). Maximum degradation is exhibited at 16 h.

Negative control TL 13-22 (Cat. No. 6747) also available.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamide
CAS 2229037-04-9
Mængde 5 mg
Molekylær formel C45H53ClN10O10S
Formel vægt 961.48
Renhed 98%
Produkttitel
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