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Beskrivelse
2'-Fluoro-iBu-G CEP is a phosphoramidite containing 5' DMT and the nucleoside guanosine (G) with 2'-Fluoro protection, for use in oligonucleotide synthesis. Located in the ideal oligo position, the highly electronegative fluorine (2'-Fluoro) modification adopts a more thermodynamically stable A-form helix on hybridization to its target. Showing improved affinity and some nuclease resistance (compared to 2'-OH), the 2'-F modification has been proven useful in antisense, siRNA, and aptamer applications. The 'standard grade' marking denotes a baseline level of purity verified with analytical methods, and proven to be suitable for most oligo synthesis requirements. This product is supplied in an amber bottle.
Funktioner:
- Fuldt kemisk navn —5'-O-(4,4'-Dimethoxytrityl) -N2- isobutyryl-2'-fluorguanosin-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidit
- Molekylformel —C 44 H 53 FN 7 O 8 P
- Base —G
- Basisbeskyttelse —iBu
- Formelvægt —857,4 g/mol
- CAS-nummer —144089-97-4
- HPLC renhed —>98 %
- 31 P NMR renhed —≥98 %
Tekniske data
Tekniske data
| Format | Pulver |
| Til brug med (udstyr) | AKTA Synthesizere, Applied Biosystems Synthesizere |
| Produkttype | 2in-Fluoro-iBu-G CEP |
| Indhold og opbevaring | Opbevares i fryseren (ved eller under -20 °C). |
| Nukleosid type | Guanosin (G) |
| Reagensfunktioner | 2in-Fluoro modificeret |
| Forsendelsestilstand | Stuetemperatur |
| Renhed | 98% |
| Reagenstype | Phosphoramidite |
| Grad | Standard |
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For Research Use Only.
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