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THEM4 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA517637
Additional Details : Weight : 0.01000kg
Description
It is not recommended to aliquot this antibody.
THEM4, also known as CTMP, binds specifically to the carboxy-terminal regulatory domain of PKB/Akt at the plasma membrane and acts as a negative regulator, reversing the phenotype of v-Akt-transformed cells. Hypermethylation of the THEM4 promoter and transcriptional downregulation of the gene has been reported in multiple glioblastomas, suggesting that epigenetic regulation of THEM4 may play a role in the progression of this cancer. Bioinformatic analysis, confirmed by in vitro testing, indicates that THEM4 is a broad-range, high activity acyl-CoA thioesterase. Recent reports have also indicated that TMEM4 is a mitochondrial protein whose overexpression is associated with an increase in mitochondrial membrane depolarization and caspase-3 and PARP cleavage, suggesting that THEM4 is involved in the apoptotic program.Specifications
| THEM4 | |
| Polyclonal | |
| 0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5 | |
| Q3UUI3, Q566R0, Q5T1C6 | |
| THEM4 | |
| Synthetic peptide corresponding to residues of human CTMP | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
| Flow Cytometry, Immunoprecipitation, Western Blot | |
| Unconjugated | |
| THEM4 | |
| 2700077M13Rik; 4921507I02Rik; Acyl-CoA thioesterase THEM4; acyl-coenzyme A thioesterase THEM4; carboxyl-terminal modulator protein; C-terminal modulator protein; CTMP; RGD1304723; THEM4; Thioesterase superfamily member 4 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 117145, 361992, 75778 | |
| -20°C | |
| Liquid |