TGM2 Monoclonal Antibody (CUB 7402), Invitrogen™

Description

MA5-12739 targets Transglutaminase II in IF, IHC (P), IP, and WB applications and shows reactivity with Canine, Guinea Pig, Human, and Rabbit samples. The MA5-12739 immunogen is purified guinea pig liver TGase II.

Transglutaminase (TGase) catalyses the crosslink of proteins by forming e-(g-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal b-sandwich, catalytic core and two C-terminal b-barrel domains. tTGase may have a role in cell death, cell proliferation, cell differentiation, and receptor-mediated endocytosis. In the Alzheimer's disease brain, the elevated tTGase activity is manifested by polymerization of a number of proteins, including Ab peptide, b-amyloid precursor protein and the tau protein, with formation of neurofibrillary tangles.