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Invitrogen™ Human TEK (TIE2) [Y897S], GST Tag Recombinant Protein
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Quantity:
1 mg
10 μg
100 μg
Unit Size:
100µg
10µg
1mg
Description
TEK (TIE2) Y897S receptor tyrosine kinase is expressed principally on vascular endothelium. Disrupting TEK Y897S function in mice results in embryonic lethality with defects in embryonic vasculature, suggesting a role in blood vessel maturation and maintenance. Angiopoietin-1 is a secreted growth factor that binds to and activates the TEK receptor tyrosine kinase. SHP2 and GRB2 are recruited to the activated TEK kinase domain and are part of the cellular responses that mediate TEK function. TEK expression is upregulated in the endothelium of vascular 'hot spots' in human breast cancer specimens. However, TEK is also overexpressed in areas of active angiogenesis in normal tissues.

Specifications
Specifications
Accession Number | Q02763 |
Concentration | See Label |
For Use With (Application) | Kinase Assay |
Formulation | 50 mM tris HCl with 0.1 mM EDTA, 0.1 mM PMSF, 0.25 mM DTT, 10 mM glutathione, 150 mM NaCl, 25% glycerol and no preservative; pH 7.5 |
Gene ID (Entrez) | 7010 |
Molecular Weight (g/mol) | 66.7 kDa |
Name | Human TEK (TIE2) [Y897S], GST Tag |
Quantity | 100 μg |
Gene Alias | TIE2 |
Common Name | TIE2 (TEK) (Y897S Mutant) |
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Product Title
Invitrogen™ Human TEK (TIE2) [Y897S], GST Tag Recombinant Protein >
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