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Invitrogen™ Human TEK (TIE2) [Y897S], GST Tag Recombinant Protein Product Code.: 17118745

Invitrogen™ Human TEK (TIE2) [Y897S], GST Tag Recombinant Protein

Product Code. 17118745
100 μg, 100µg
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Quantity:
1 mg
10 μg
100 μg
Unit Size:
100µg
10µg
1mg
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Product Code. 17118745

Brand: Invitrogen™ A32878

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Recombinant Protein

TEK (TIE2) Y897S receptor tyrosine kinase is expressed principally on vascular endothelium. Disrupting TEK Y897S function in mice results in embryonic lethality with defects in embryonic vasculature, suggesting a role in blood vessel maturation and maintenance. Angiopoietin-1 is a secreted growth factor that binds to and activates the TEK receptor tyrosine kinase. SHP2 and GRB2 are recruited to the activated TEK kinase domain and are part of the cellular responses that mediate TEK function. TEK expression is upregulated in the endothelium of vascular 'hot spots' in human breast cancer specimens. However, TEK is also overexpressed in areas of active angiogenesis in normal tissues.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q02763
Concentration See Label
For Use With (Application) Kinase Assay
Formulation 50 mM tris HCl with 0.1 mM EDTA, 0.1 mM PMSF, 0.25 mM DTT, 10 mM glutathione, 150 mM NaCl, 25% glycerol and no preservative; pH 7.5
Gene ID (Entrez) 7010
Molecular Weight (g/mol) 66.7 kDa
Name Human TEK (TIE2) [Y897S], GST Tag
Quantity 100 μg
Gene Alias TIE2
Common Name TIE2 (TEK) (Y897S Mutant)
KinaseFamily TIE Kinase Family
Protein Length 771-end
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag GST-tag
Content And Storage -80°C, Avoid Freeze/Thaw Cycles
Shipping Condition Dry Ice
Expression System Insect cells
Protein Form Recombinant, Active, Catalytic
Form Liquid
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