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Tocris Bioscience™ TASP 0433864
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Artikelnummer. 18741068
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10 mg
50 mg
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18741068 10 mg
18733978 50 mg
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Artikelnummer. 18741068 Leverandør Tocris Bioscience™ Leverandørnr. 5362/10

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Beskrivelse

Selective mGlu2 receptor positive allosteric modulator

TASP 0433864 is a selective mGlu2 receptor positive allosteric modulator (EC50 values are 199 and 206 nM for human and rat receptors, respectively). Exhibits negligible activity against a range of neurotransmitter targets, except 5-HT2B and MAO-B (72 and 92% inhibition at 10 μM, respectively). Potentiates inhibitory effect of DCG IV (Cat. No. 0975) on excitatory postsynaptic potentials in hippocampal slices and ketamine- and methamphetamine-induced increases in locomotor activity in rats and mice.
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Tekniske data

Kemisk navn eller materiale (2S)-2-[[4-(1,1-Dimethylethyl)phenoxy]methyl]-2,3-dihydro-5-methylimidazo[2,1-b]oxazole-6-carboxamide
CAS 1431980-60-7
Synonym mGlu2 receptor positive allosteric modulator
Mængde 10 mg
Opløselighed Soluble to 100mM in DMSO and to 20mM in ethanol
Molekylær formel C18H23N3O3
Formel vægt 329.39
Fysisk form Solid
Farve White
Produkttype Bioactive Small Molecule
Renhed >98%
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For Research Use Only.

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