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TAS0728, MedChemExpress

Artikelnummer. 16427217
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Mængde:
5 mg
10 mg
50 mg
100 mg
Pakningsstørrelse:
50mg
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Artikelnummer. 16427217 Leverandør Medchem Express Leverandørnr. HY1115535mg

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Beskrivelse

MedChemExpress TAS0728 is a potent, selective, orally active, irreversible and covalent-binding HER2 inhibitor, with an IC50 of 13 nM. TAS0728 also shows IC50s of 4.9, 8.5, 31, 65, 33, 25 and 86 nM for BMX、HER4、BLK、EGFR、JAK3、SLK and LOK respectively. Furthermore, TAS0728 exhibits robust and sustained inhibition of the phosphorylation of HER2HER3, and downstream effectors.

TAS0728 is a potent, selective, orally active, irreversible and covalent-binding HER2 inhibitor, with an IC50 of 13 nM. TAS0728 also shows IC50s of 4.9, 8.5, 31, 65, 33, 25 and 86 nM for BMX、HER4、BLK、EGFR、JAK3、SLK and LOK respectively. Furthermore, TAS0728 exhibits robust and sustained inhibition of the phosphorylation of HER2HER3, and downstream effectors.

Tekniske data

Kemisk navn eller materiale TAS0728
CAS 2088323-16-2
Farve White
Renhedsgrad noter Research
Molekylær formel C26H32N8O3
Mængde 5 mg
Opløselighedsinformation DMSO : 125 mg/mL (247.73 mM; Need ultrasonic)
SMIL NC1=C2C(N([C@H]3CN(C(C=C)=O)CCC3)N=C2C(NC4=CC=C(CC(N(C)C)=O)C(C)=C4C)=O)=NC=N1
Molekylvægt (g/mol) 504.58
Formel vægt 504.58
Procent renhed 99.05%
Grad Research
Fysisk form Solid
Til brug med (applikation) Cancer-Kinase/protease
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Research purposes only

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