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STEMCELL Technologies Tamoxifen

Artikelnummer. 17160102
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Mængde:
500 mg
5 g
10 g
Pakningsstørrelse:
10g
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Artikelnummer. Mængde unitSize
17160102 10 g 10g
17140102 500 mg -
17150102 5 g -
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Artikelnummer. 17160102 Leverandør STEMCELL Technologies Leverandørnr. 72666

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Beskrivelse

Estrogen signaling pathway modulator; Modulates selective estrogen receptor and estrogen-related receptor

  • Tamoxifen is a selective estrogen receptor modulator (SERM), with tissue-specific antagonistic or agonistic effects
  • Receptor activation leads to the formation of homo- and hetero-dimers, which in turn interact with accessory proteins to regulate gene transcription
  • Tamoxifen is commonly used to activate Cre-ER in transgenic conditional models
  • Used in transgenic models to induce Cre-mediated recombination in conjunction with Cre-ER, a fusion protein consisting of Cre recombinase and a mutant form of the estrogen receptor hormone-binding domain that specifically binds tamoxifen but not estrogen (Feil et al.; Zhang et al.)
  • Inhibits growth in the human breast cancer cell line, MCF-7 (Katzenellenbogen et al.)
  • Antagonist of estrogen receptor action in breast tissue and breast cancer cells (Abe et al.; Horwitz et al.)

Tekniske data

CAS 10540-29-1
Synonym trans-Tamoxifen
Mængde 10 g
Molekylær formel C26H29NO
Renhed ≥95%
Produkttitel
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