missing translation for 'onlineSavingsMsg'
Learn More

Invitrogen™ Human TAK1 Synthetic Peptide

Synthetic Peptide

Brand:  Invitrogen™ PEP0201

Additional Details : Weight : 0.01000kg

Product Code. 15246419

  • 1002.00 DKK / 50µg
Estimated Shipment: 11-04-2024
to see stock.

Please to purchase this item. Need a web account? Register with us today!


Description

Description

TAK1 Synthetic Peptide, PEP-0201, from Invitrogen.

TAK1 (also known as MAP3K7), a part of the serine/threonine kinase family, is a versatile protein with many signaling functions. Originally identified as a TGF- beta-activated kinase, TAK1 interacts with TGF- beta-receptor and TRAF6 to modulate TGF- beta activation of JNK and p38. It has additional roles in activation of p38 and JNK through Wnt, BMP, and activin signaling pathways as well in response to thyroid hormone, osmotic stress, endothelin, and ephrine. Through activation of von Hippel-Lindau tumor suppressor expression, TAK1 represses PDGF-B, integrin beta1 and integrin beta5, promoting proper wound healing. TAK1 also plays an essential role in IKK activation in numerous signaling pathways including IL-1, IL-6, IL-18, TNF, CD40, TLR, and RIG-I. Activation of the TAK1-IKK pathway requires TAB2/3 and ubiquitination. In this process, TAB2/3 binds to the C-terminal region of TAK1 and becomes polyubiquitinated, TAK1 is autophosphorylated at Thr178, Thr184, Thr187 and Ser192, and finally TAK1 phosphorylates IKK- beta. Additionally, TAK1 represses human telomerase reverse transcriptase suggesting a role in regulation of cell lifespan. This peptide corresponds to 14 amino acids near the amino terminus of human TAK1 (NT).PEP-0201 can be used as a blocking peptide with polyclonal antibody PA5-20083.
Specifications

Specifications

6885
purified
Human TAK1
-20°C
Liquid
Blocking Assay, Control
No
Peptide
RUO - research use only
Human
O43318
200 μg/mL
Synthetic Peptide
PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2
MAP3K7
0.02% sodium azide
50 μg
PBS
Product Suggestions

Product Suggestions

Videos
SDS
Documents

Documents

Certificates
Special Offers

Special Offers