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  7. TAK-659 hydrochloride, MedChemExpress

TAK-659 hydrochloride, MedChemExpress

Artikelnummer. 16445927
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16445927 5 mg
16432666 25 mg
16429746 50 mg
16423198 10 mg
16420046 2 mg
16434476 100 mg
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Artikelnummer. 16445927 Leverandør Medchem Express Leverandørnr. HY100867A

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Beskrivelse

MedChemExpress TAK-659 hydrochloride is a highly potent, selective, reversible and orally available dual inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), with an IC50 of 3.2 nM and 4.6 nM for SYK and FLT3, respectively. TAK-659 hydrochloride induces cell death in tumor cells but not in nontumor cells, and with potential for the treatment of chronic lymphocytic leukemia (CLL).

TAK-659 hydrochloride is a highly potent, selective, reversible and orally available dual inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), with an IC50 of 3.2 nM and 4.6 nM for SYK and FLT3, respectively. TAK-659 hydrochloride induces cell death in tumor cells but not in nontumor cells, and with potential for the treatment of chronic lymphocytic leukemia (CLL).

Tekniske data

Kemisk navn eller materiale TAK-659 hydrochloride
CAS 1952251-28-3
Farve White
Renhedsgrad noter Research
Molekylær formel C17H22ClFN6O
Mængde 5 mg
Opløselighedsinformation H2O : 2 mg/mL (5.25 mM; ultrasonic and adjust pH to 3 with HCl) ∣DMSO : < 1 mg/mL (insoluble or slightly soluble)
SMIL FC1=C(N[C@@H]2CCCC[C@@H]2N)N=C(C3=CN(C)N=C3)C4=C1CNC4=O.Cl
Molekylvægt (g/mol) 380.85
Formel vægt 380.85
Procent renhed 98.13%
Grad Research
Fysisk form Solid
Til brug med (applikation) Cancer-Kinase/protease
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Research purposes only

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