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TAK-243, MedChemExpress

Artikelnummer. 16493038
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Mængde:
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10 mg
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Artikelnummer. Mængde
16493038 10 mg
16465777 5 mg
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Artikelnummer. 16493038 Leverandør Medchem Express Leverandørnr. HY100487

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Beskrivelse

MedChemExpress TAK-243 (MLN7243) is a first-in-class, selective ubiquitin activating enzyme, UAE (UBA1) inhibitor (IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as well as global protein ubiquitination. TAK-243 (MLN7243) induces endoplasmic reticulum (ER) stress, abrogates NF-κB pathway activation and promotes apoptosis.

TAK-243 (MLN7243) is a first-in-class, selective ubiquitin activating enzyme, UAE (UBA1) inhibitor (IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as well as global protein ubiquitination. TAK-243 (MLN7243) induces endoplasmic reticulum (ER) stress, abrogates NF-κB pathway activation and promotes apoptosis.

Tekniske data

Kemisk navn eller materiale TAK-243
Fysisk form Solid
CAS 1450833-55-2
Farve Off-White
Mængde 10 mg
Renhedsgrad noter Research
Molekylær formel C19H20F3N5O5S2
Til brug med (applikation) Cancer-programmed cell death
Synonym MLN7243
Opløselighedsinformation DMSO : 50 mg/mL (96.24 mM; Need ultrasonic) ∣H2O : 1 mg/mL (1.92 mM; Need ultrasonic)
SMIL O=S(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](NC2=CC=NC3=CC(C4=CC=CC(SC(F)(F)F)=C4)=NN23)C1)(N)=O
Molekylvægt (g/mol) 519.52
Formel vægt 519.52
Procent renhed 98.0%
Grad Research
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Research purposes only

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