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Thermo Scientific™ Tacrolimus, 99+%
Tacrolimus, CAS # 104987-11-3, also known as FK-506 or fujimycin, is a macrolide compound that exhibits immunosuppressant, neuroprotective, and neuroregenerative activities and can inhibit T-cell proliferation and activation.
Brand: Thermo Scientific™ J63571.MF
| Mængde | 50 mg |
|---|
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Beskrivelse
This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.
General Description
• Tacrolimus is a macrolide isolated from Streptomyces tsukubaensis, that shows immunosuppressant, neuroprotective, and neuroregenerative activities, having the ability to block T-cell proliferation and activation in response to antigenic or mitogenic stimulation, in vitro and in vivo
• Tacrolimus interacts with the immunophilins cyclophilin and FKBP-12. Tacrolimus binds to the FKBP-12 protein (FK506 binding protein) and forms a complex with calcium-dependent proteins. This FKBP12-FK506 complex inhibits calcineurin phosphatase activity, resulting in decreased cytokine production, inhibition of T-lymphocyte signal transduction
• Tacrolimus also inhibits the transcription for genes that encode IL-3, IL-4, IL-5, GM-CSF, and TNF, all of which are involved in the early stages of T-cell activation
• This compound can also inhibit the release of pre-formed mediators from skin mast cells and basophils and downregulate the expression of FceRI on Langerhans cells
Application
• Tacrolimus has been studied in vitro to understand its impact on neutrophil production and/or survival • It is applied to suppress the inflammation in ulcerative cells
• It is used as a research tool in chemically induced dimerization applications in biology
• It has been used in in vitro studies to investigate its effect on human monocyte-derived dentritic cells
• This compound has been used in a hydrogel-based drug delivery system and its impact was evaluated and monitored using in vivo imaging
Kemiske identifikatorer
| 104987-11-3 | |
| FK-506; Fugimycin | |
| Powder | |
| White to Off-white | |
| Freely soluble in DMSO or ethanol; Poorly soluble in water |
| 804.02g/mol | |
| -30°C to -10°C | |
| Interacts with the immunophilins cyclophilin and FKBP-12 | |
| 120°C to 125°C | |
| ≥99% |
Tekniske data
| 50 mg | |
| -30°C to -10°C | |
| Interacts with the immunophilins cyclophilin and FKBP-12 | |
| C44H69NO12 | |
| FK-506; Fugimycin | |
| Freely soluble in DMSO or ethanol; Poorly soluble in water |
| White to Off-white | |
| Powder | |
| 104987-11-3 | |
| 804.02g/mol | |
| 120°C to 125°C | |
| ≥99% |
Sikkerhed og håndtering
Produktidentifikator
Signalord
Farekategori
Hazard Statement
Precautionary Statement
Supplemental information
- Tacrolimus
Signalord
- Fare
Farekategori
- Akut toksicitet Kategori 3
Hazard Statement
- H301-Giftig ved indtagelse.
Precautionary Statement
- P264-Vask grundigt efter brug.
- P301+P310-I TILFÆLDE AF INDTAGELSE: Ring omgående til en GIFTINFORMATION/læge
Supplemental information
- MIXTURE LIST-Contain: Tacrolimus
Product Title
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