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T-bet Mouse anti-Human, Mouse, Rat, Clone: eBio39D (39D, 3-9D), eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-5824-80

Additional Details : Weight : 0.01000kg

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Product Code. 15297487

  • 792.00 DKK / 25µg


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Description

Description

T-bet, also known as TBX21, is a T-cell specific transcription factor containing a single T-box DNA-binding domain. It controls the expression of the TH1 cytokine, interferon-gamma. Both Th1 and Th17 cells are crucial in immune regulation and autoimmune disease development. T-bet initiates Th1 lineage development from naive Th precursor cells and directs T cell differentiation to Th1 versus Th17. T-bet is cooperating with Stat4 (signal tranducer and activator of transcription 4) in programming chromatin architecture for Th1 gene expression. Genetic variations in T-bet are associated with susceptibility to aspirin-induced asthma and nasal polyps.
Specifications

Specifications

T-bet
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q9UL17, Q9JKD8
T-PET, T-bet, TBET, TBLYM, T-box expressed in T cells; T-box protein 21; T-box transcription factor TBX21; T-cell-specific T-box transcription factor T-bet; transcription factor TBLYM
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human, Mouse, Rat
Immunoprecipitation, Western Blot
eBio39D (39D, 3-9D)
Unconjugated
TBX21
Liquid
TBX21
IgG1
25 μg
4° C
Primary
30009, 303496, 57765
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