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SU 6668, Tocris Bioscience™
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Artikelnummer. 18085152
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50 mg
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18085152 10 mg
18055682 50 mg
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Artikelnummer. 18085152 Leverandør Tocris Bioscience Leverandørnr. 3335/10

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Beskrivelse

PDGFR, VEGFR and FGFR inhibitor

ATP-competitive PDGFR, VEGF and FGFR inhibitor (IC50 values are 0.06, 2.43, 3.04 and > 100 μM at PDGFRβ, VEGFR2, FGFR1 and EGFR respectively). Inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC50 values are 0.41, 9.3 and 16.5 μM for VEGF, FGF and PDGF-stimulated growth respectively) and induces > 75% growth inhibition against a broad range of tumor types in vivo. Exhibits antiangiogenic, anti-inflammatory, antimetastatic and proapoptotic activity and is orally active.
TRUSTED_SUSTAINABILITY

Kemiske identifikatorer

CAS 252916-29-3
Molekylær formel C18H18N2O3
Molekylvægt (g/mol) 310.353
InChI nøgle NHFDRBXTEDBWCZ-NTEUORMPSA-N
Synonym 3-2,4-dimethyl-5-e-2-oxo-1h-indol-3-ylidene methyl-1h-pyrrol-3-yl propanoic acid, e-3-2,4-dimethyl-5-2-oxoindolin-3-ylidene methyl-1h-pyrrol-3-yl propanoic acid, tsu 68, tsu-68 su6668,orantinib, 3-2,4-dimethyl-5-3e-2-oxo-1h-indol-3-ylidene methyl-1h-pyrrol-3-yl propanoic acid, 3-2,4-dimethyl-5-e-2-oxo-1,2-dihydro-3h-indol-3-ylidene methyl-1h-pyrrol-3-yl propanoic acid, tsu-68 random configuration, z-3-2,4-dimethyl-5-2-oxoindolin-3-ylidene-methyl-1h-pyrrol-3-yl propanoic acid, 3-2,4-dimethyl-5-2-oxoindolin-3-ylidene methyl-1h-pyrrol-3-yl propanoic acid, 5-1,2-dihydro-2-oxo-3h-indol-3-ylidene methyl-2,4-dimethyl-1h-pyrrole-3-propanoic acid
PubChem CID 5995546
IUPAC navn 3-[2,4-dimethyl-5-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid
SMIL CC1=C(NC(=C1CCC(=O)O)C)C=C2C3=CC=CC=C3NC2=O

Tekniske data

Kemisk navn eller materiale SU 6668
Mængde 10 mg
Formel vægt 310.35
Procent renhed >99%
Produkttitel
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