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Tocris Bioscience™ STING agonist C53
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Artikelnummer. 18767546
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50 mg
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Artikelnummer. Mængde
18767546 50 mg
18717306 10 mg
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Artikelnummer. 18767546 Leverandør Tocris Bioscience™ Leverandørnr. 7741/50

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Beskrivelse

Pan-polymorph STING agonist

STING agonist C53 is an activator of human STING (EC50 = 185 nM). It promotes the oligomerization and activation of human STING through a mechanism orthogonal to that of cGAMP. STING agonist C53 increases activity of STING variants in HEK293T cells (107%, 92% and 92% reporter activity against H232, R232 and HAQ, respectively). It induces phosphorylation of STING variants in human tumor cell lines and PBMCs. STING agonist C53 is active at human but not mouse STING. Orally bioavailable.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale 1-[(2-Chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-1 H-indole-6-carboxamide
CAS 2259624-71-8
Mængde 50 mg
Mål STING Agonists
Molekylær formel C25H19ClF4N2O2
Renhed 0.98
Produkttitel
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