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Staurosporine, MP Biomedicals™
Possesses inhibitory activity against fungi and yeasts. Staurosporine, MP Biomedicals is an antibiotic that is isolated from Streptomyces species. It is a potent inhibitor of phospholipid/Ca2+-dependent protein kinases and is used to study the involvement
Brand: MP Biomedicals 0219140090
| Quantity | 500 μg |
|---|
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Description
Starosporin is used to study the involvement of protein kinases in signal transduction pathways. It arrests normal cells in the G1 checkpoint and is a potent inhibitor of Protein kinase C and other protein kinases in vitro and in cultured cells. It is an inducer of apoptosis in many mammalian cell types.
- Potent inhibitor of phospolipid/calcium dependent and cyclic nucleotide dependent protein kinases
- Useful as a tool for studies on protein phosphorylation in the regulation of cellular functions
- Inhibits the upregulation of VEGF expression in tumor cells
- Partially reverses MDR, sensitizing cells with MDR phenotype to cytotoxic agents
- Inhibits Pgp phosphorylation (functional significance of Pgp phosphorylation is ill defined)
Chemical Identifiers
| 62996-74-1 | |
| 466.541 | |
| Staurosporin, Antibiotic AM-2282 | |
| CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC |
| C28H26N4O3 | |
| HKSZLNNOFSGOKW-ZYSRIHRCSA-N | |
| 49831000 |
Specifications
| Powder | |
| 237°C | |
| C28H26N4O3 | |
| May be reconstituted by dissolving the lyophilized reagent in DMSO (5mg/mL, clear, colorless solution), DMF, ethyl acetate (5mg/mL, clear colorless solution) or methanol or water. | |
| CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC | |
| 49831000 | |
| ≥98% |
| 62996-74-1 | |
| 500 μg | |
| Staurosporin, Antibiotic AM-2282 | |
| HKSZLNNOFSGOKW-ZYSRIHRCSA-N | |
| 466.541 | |
| 466.5 |
Safety and Handling
Product Identifier
Signal Word
Hazard Category
Hazard Statement
Precautionary Statement
Supplemental information
- Staurosporine
Signal Word
- Danger
Hazard Category
- Carcinogenicity Category 1B
- Germ cell mutagenicity Category 1B
Hazard Statement
- H340-May cause genetic defects.
- H350-May cause cancer.
Precautionary Statement
- P101-If medical advice is needed, have product container or label at hand.
- P102-Keep out of reach of children.
- P103-Read label before use.
- P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
- P405-Store locked up.
- P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.
Supplemental information
- MIXTURE LIST-Contains : Staurosporine
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Product Title
Staurosporine, MP Biomedicals™ > 500μg
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