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Tocris Bioscience™ ST 034307
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Artikelnummer. 30000965
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10 mg
50 mg
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Artikelnummer. Mængde
30000965 50 mg
30000896 10 mg
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Artikelnummer. 30000965 Leverandør Tocris Bioscience™ Leverandørnr. 6271/50

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Beskrivelse

Adenylyl cyclase 1 (AC1) inhibitor; analgesic and active in vivo

ST 034307 is an adenylyl cyclase 1 (AC1) inhibitor (IC50 = 2.3 μM). Exhibits some selectivity for AC1 over other AC isoforms, with no significant activity against AC8. Inhibits Ca2+/calmodulin-stimulated cAMP accumulation in hippocampal homogenates. Enhances μ opioid receptor (MOR)-mediated inhibition of AC1 in cellular assays and inhibits development and maintenance of MOR-mediated sensitization of AC1. ST 034307 relieves pain without causing tolerance in mouse models of pain. Active in vivo. Analgesic.
TRUSTED_SUSTAINABILITY

Kemiske identifikatorer

CAS 133406-29-8
Molekylær formel C10H4Cl4O2

Tekniske data

Kemisk navn eller materiale 6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one
Mængde 50 mg
Opløselighed Soluble to 100mM in DMSO and to 20mM in ethanol
Formel vægt 297.95
Fysisk form Solid
Renhed >98%
Molekylvægt (g/mol) 297.94
Produkttitel
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