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Tocris Bioscience™ SR 95531 hydrobromide

Artikelnummer. 30001219
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30001219 10 mg
30000713 50 mg
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Artikelnummer. 30001219 Leverandør Tocris Bioscience™ Leverandørnr. 1262/10

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Beskrivelse

Competitive and selective GABAA antagonist

SR 95531 hydrobromide is a selective, competitive GABAA receptor antagonist and allosteric inhibitor (IC50 = 200 nM). SR 95531 displaces [3H]-GABA from rat brain membranes with a Ki of 150 nM. Unlike Bicuculline (Cat. No. 0130), SR 95531 selectively antagonizes GABA-induced Cl- currents with little action on Pentobarbitone -induced currents (Cat. No. 4579). SR 95531 can act as an agonist at high concentrations (>100 μM) and is a weak agonist at GABAA receptors with α1β2(Y157S)γ2L subunits. SR 95531 also acts as a competitive antagonist of recombinant glycine receptors and exhibits greater potency at glycine receptors containing β subunits.
TRUSTED_SUSTAINABILITY

Kemiske identifikatorer

CAS 104104-50-9
Molekylær formel C15H18BrN3O3

Tekniske data

Kemisk navn eller materiale SR 95531 hydrobromide
Mængde 10 mg
Formel vægt 368.23
Renhed >98%
Molekylvægt (g/mol) 368.231
Produkttitel
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