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Thermo Scientific Chemicals SP600125, 98%, Thermo Scientific Chemicals

Catalog Number p-7070128
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Quantity:
50 mg
100 mg
This item is not returnable. View return policy
To receive the discount customers must purchase three of the same product at list price in a single order to receive 33.33% discount. There is no limit to the multiples of 3 that customers can buy. Use promo code ”21615” to get your promotional price
129-56-6
C14H8N2O
1,9-Pyrazoloanthrone;
This item is not returnable. View return policy
To receive the discount customers must purchase three of the same product at list price in a single order to receive 33.33% discount. There is no limit to the multiples of 3 that customers can buy. Use promo code ”21615” to get your promotional price
129-56-6
C14H8N2O
1,9-Pyrazoloanthrone;

SP 600125 is a potent and reversible inhibitor of JNK1-3 with an IC50 value of 0.11 M.1 It is cell-permeable and dose-dependently inhibits c-Jun phosphorylation in cells, blocking the expression of COX-2 and TNF-α in monocytes and IL-10, TNF-α, and IFN-γ in T-cells. SP 600125 also prevents apoptosis in many cell types, including B-cells, and inhibits autophagy in HeLa cells. Competitively and reversibly inhibits JNK1, 2 and 3 (IC50 = 40 - 90 nM) with negligible activity at ERK2, p38β and a range of enzymes (IC50 > 10 ?M). Shown to have reduced selectivity over other protein kinases under certain conditions. Prevents BMP9-induced osteogenic differentiation of MSCs.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

TRUSTED_SUSTAINABILITY
Quantity 50 mg
Description Yellow to brown
Content And Storage -30°C to -10°C
Formula Weight 220.23
Solubility Soluble in DMSO at approx. 20mg/ml
Product Type SP600125, 99%
Form Solid
InChI Key ACPOUJIDANTYHO-UHFFFAOYSA-N
SMILES O=C1C2=C3C(NN=C3C3=CC=CC=C13)=CC=C2
IUPAC Name 14,15-diazatetracyclo[7.6.1.0²,⁷.0¹³,¹⁶]hexadeca-1(15),2,4,6,9(16),10,12-heptaen-8-one
Molecular Weight (g/mol) 220.23
Assay 99%
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RUO – Research Use Only

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