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Tocris Bioscience™ SP 600125

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Mængde:
10 mg
50 mg
Beskrivelse
SP 600125 is a selective JNK inhibitor. Competitively and reversibly inhibits JNK1, 2 and 3 (IC50 = 40 - 90 nM) with negligible activity at ERK2, p38β and a range of enzymes. Active in vivo. Exhibits reduced selectivity over other protein kinases under certain conditions. SP 600125 protects renal tubular epithelial cells from ischemia/reperfusion-induced apoptosis. Promotes chondrogenesis of bone mesenchymal stem cells by inhibition of TNF-α-induced inflammation. Adipogenesis from MSCs is also promoted by SP 600125. Essential component of medium for maintaining stem cells in naive pluripotent state.
Tekniske data
Tekniske data
| Kemisk navn eller materiale | SP 600125 |
| Mængde | 10 mg |
| Formel vægt | 220.23 |
| Renhed | >98% |
| Molekylvægt (g/mol) | 220.231 |
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