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Tocris Bioscience™ SP 100030
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Artikelnummer. 18722689
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10 mg
50 mg
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18722689 50 mg
18753419 10 mg
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Artikelnummer. 18722689 Leverandør Tocris Bioscience™ Leverandørnr. 5309/50

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Beskrivelse

NF-κB and AP-1 dual inhibitor

SP 100030 is a potent dual inhibitor of NF-κB and AP-1 transcriptional activity (IC50 = 50 nM). Blocks production of IL-2, IL-8 and TNF-α from Jurkat T cells. Inhibits cytokine production selectively in T cells; exhibits minimal inhibition of cytokine production in other cell types. Decreases arthritic severity in a mouse model of collagen-induced arthritis. Also ameliorates muscle wasting in a rat model of cancer cachexia.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide
CAS 154563-54-9
Mængde 50 mg
Mål NFkB/IkB Inhibitors
Molekylær formel C14H5ClF9N3O
Formel vægt 437.65
Renhed >99%
Produkttitel
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