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Tocris Bioscience™ Sorafenib
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Artikelnummer. 18785476
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Mængde:
10 mg
50 mg
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Artikelnummer. Mængde
18785476 10 mg
18766326 50 mg
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Artikelnummer. 18785476 Leverandør Tocris Bioscience™ Leverandørnr. 6814/10

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Beskrivelse

Potent Raf-1 inhibitor; also inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and cKIT

Sorafenib is a potent Raf inhibitor (IC50 values are 6, 22 and 38 nM for Raf-1, wild-type BRAF and V599E BRAF mutant, respectively). Also inhibits mVEGFR-2, mVEGFR-3, mPDGFR-β, Flt-3, cKIT and VEGFR-2 (IC50 values are 15, 20, 57, 58, 68 and 90 nM, respectively). Inhibits MAPK pathway in colon, pancreatic and breast cancer cells expressing mutant KRAS and mutant or wt BRAF in vitro. Exhibits antitumor activity in colon, breast and non small-cell lung cancer xenograft models. Also induces ferroptosis in hepatocellular carcinoma cells in vitro.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide
CAS 284461-73-0
Mængde 10 mg
Molekylær formel C21H16ClF3N4O3
Formel vægt 464.82
Renhed 98%
Produkttitel
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