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Tocris Bioscience™ SNIPER(ER)-87
GREENER_CHOICE

Artikelnummer. 18719316
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Mængde:
5 mg
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Artikelnummer. Mængde
18719316 5 mg
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Artikelnummer. 18719316 Leverandør Tocris Bioscience™ Leverandørnr. 7120/5

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Beskrivelse

Potent and selective ERα Degrader (SNIPER)

SNIPER(ER)-87 is a potent and selective estrogen receptor α (ERα) Degrader (Specific and Nongenetic IAP-dependent Protein Erasers or SNIPER) (DC50 = 3 nM). SNIPER(ER)-87 comprises the IAP binding ligand LCL 161 (Cat .No. 7178) joined by a linker to the estrogen-binding moiety 4-hydroxytamoxifen (Cat. No. 3412). The product decreases ERα levels in breast cancer cells in vitro and in mouse ovaries in vivo. SNIPER(ER)-87 also reduces ERα levels and inhibits tumor proliferation in breast cancer xenograft mouse models.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale (2 S)-N-[(1 S)-1-Cyclohexyl-2-[(2 S)-2-[4-[3-[[14-[4-[1-(4-hydroxyphenyl)-2-phenyl-1-buten-1-yl]phenoxy]-12-methyl-11-oxo-3,6,9-trioxa-12-azatetradec-1-yl]oxy]benzoyl]-2-thiazolyl]-1-pyrrolidinyl]-2-oxoethyl]-2-(methylamino)propanamide
CAS 2222354-91-6
Mængde 5 mg
Mål Active Degraders
Molekylær formel C59H73N5O10S
Renhed 0.98
Produkttitel
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