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Tocris Bioscience™ SMIP 004
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Artikelnummer. 18707056
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50 mg
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Artikelnummer. Mængde
18707056 10 mg
18787506 50 mg
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Artikelnummer. 18707056 Leverandør Tocris Bioscience™ Leverandørnr. 7192/10

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Beskrivelse

SKP2 (S-phase kinase-associated protein 2) inhibitor; upregulates p27 and arrests cell cycle in G1 phase

SMIP 004 is a SKP2 (S-phase kinase-associated protein 2) inhibitor. Upregulates p27 and activates the unfolded protein response (UPR) in LNCaP prostate cancer cells overexpressing SKP2. Also induces oxidative stress. Induces proteasomal degradation of cyclin D1 and acts as CDK2 inhibitor. Arrests cell cycle in G1 phase and induces apoptosis in prostate cancer cells, but not normal cells in vitro. Inhibits growth of breast and prostate cancer xenografts in mice. Also induces autophagy and reduces replication of MERS-CoV in VeroB4 cells.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale N-(4-Butyl-2-methylphenyl)acetamide
CAS 143360-00-3
Mængde 10 mg
Mål Ubiquitin Ligase (E3) Inhibitors
Molekylær formel C13H19NO
Renhed 0.98
Produkttitel
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