missing translation for 'onlineSavingsMsg'
Learn More
Thermo Scientific™ SM(PEG)2 (PEGylated SMCC crosslinker) Product Code.: 11831265
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Crosslinking, Labeling and Protein Modification
  5. Crosslinking Reagents
  6. Thermo Scientific™ SM(PEG)2 (PEGylated SMCC crosslinker)

Thermo Scientific™ SM(PEG)2 (PEGylated SMCC crosslinker)

Product Code. 11831265 Shop All Thermo Scientific Products
100 mg, 100mg
Click to view available options
Quantity:
100 mg
1 g
Unit Size:
100mg
Each
This item is not returnable. View return policy
Regulatory: This product contains a substance listed in Annex XVII to REACH Regulation (EC) No 1907/2006, all customers must complete a declaration before delivery.

Product Code. 11831265

Brand: Thermo Scientific™ 22102

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy
Regulatory: This product contains a substance listed in Annex XVII to REACH Regulation (EC) No 1907/2006, all customers must complete a declaration before delivery.

Description

Crosslink amines to sulfhydryls with these crosslinkers containing NHS-ester and maleimide groups at ends of water-soluble polyethylene glycol spacer arms (17.6 to 95.2A).

Thermo Scientific™ Pierce SM(PEG)n is a series of amine-to-sulfhydryl crosslinkers that differ in length from 17.6 to 95.2 Ås as a result of polyethylene glycol spacer arms containing n equals 2 to 24 ethylene glycol units.

The SM(PEG)n reagents are six crosslinkers that have identical amine- and sulfhydryl-reactive groups but differ in length as a result of spacer arms composed of different numbers of ethylene glycol units. Their structures (shown below) have the form NHS-(PEG)n-Maleimide, where n represents 2, 4, 6, 8, 12 or 24 polyethylene glycol (PEG) units. Each SM(PEG)n reagent is produced at the specified length without contamination from analogs of other lengths.The availability of this set of reagents makes it possible to optimize crosslinking experiments to obtain the best conjugate efficiency and function for the intended application or analysis method. Considered together with AMAS (Part No. 22295) and the popular SMCC (Part No. 22360), these reagents allow for amine-to-sulfhydryl crosslinking across spaces ranging from 4.4 to 95.2Ă…. In addition, the hydrophilic PEG content of SM(PEG)n reagents adds to the aqueous solubility of these crosslinkers and their conjugates. PEG is also less immunogenic than other types of crosslinker spacers, making these reagents ideal for immunogen preparation.

Highlights:

  • Homologous series of increasing spacer arm length, ideal for optimizing conjugation of protein interactions
  • Water-soluble polyethylene glycol (PEG) spacer arms help to maintain or increase solubility of crosslinked proteins
  • Reagents readily dissolve in DMSO for subsequent dilution in aqueous reaction buffers
  • Reactive groups: NHS ester and maleimide
  • Reactive toward: amino and sulfhydryl groups

NHS-PEG2-Maleimide

  • Two ethylene oxide subunits
  • Alternate names: Mal-dPEG2-NHS, NHS-PEG2-Maleimide
  • Molecular formula C18H23N3O9
  • Spacer arm length 17.6Ă…
  • Mass added to target per crosslink 310.12
  • MW 425.39

NHS-PEG4-Maleimide

  • Four ethylene oxide subunits
  • Alternate names Mal-dPEG4-NHS, NHS-PEG4-Maleimide
  • Molecular formula C22H31N3O11
  • Spacer arm length 24.6Ă…
  • Mass added to target per crosslink 398.17
  • MW 513.50&

NHS-PEG6-Maleimide

  • Six ethylene oxide subunits
  • Alternate names Mal-dPEG6-NHS, NHS-PEG6-Maleimide
  • Molecular formula C26H39N3O13
  • Spacer arm length 32.25Ă…
  • Mass added to target per crosslink 486.20
  • MW 601.60

NHS-PEG8-Maleimide

  • Eight ethylene oxide subunits
  • Alternate names Mal-dPEG8-NHS, NHS-PEG8-Maleimide
  • Molecular formula C30H47N3O15
  • Spacer arm length 39.2Ă…
  • Mass added to target per crosslink 574.27
  • MW 689.71

NHS-PEG12-Maleimide

  • 12 ethylene oxide subunits Mal-dPEG12-NHS, NHS-PEG12-Maleimide
  • Molecular Formula C38H63N3O19
  • Spacer arm length 53.4Ă…
  • Mass added to target per crosslink 750.38
  • MW 865.92
TRUSTED_SUSTAINABILITY

Specifications

Chemical Reactivity Amine-Sulfhydryl
Cleavable No
Molecular Weight (g/mol) 425.39
PEGylated Yes
Spacer Arm Length 17.6 AĚŠ
Content And Storage Upon receipt store desiccated at -20°C.
Cell Permeability No
Shipping Condition Ambient
Product Line Pierce™
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Reactive Moiety Maleimide, NHS Ester
Spacer Medium (10 to 30 AĚŠ)
Form Solid
Quantity 100 mg
Solubility Water
Format Standard, Single-use
Water Soluble Yes
Product Type Crosslinker
Show More Show Less

Certificates

Certificates

A lot number is required to show results for certificates. To find your lot number on previous orders use our order status area.

5 results found
Lot Number Certificate Type Date Product Code
Lot NumberSH249291 Certificate TypeCertificate of Analysis Date29/01/2025 Product Code22102
Lot NumberZK390422 Certificate TypeCertificate of Analysis Date16/12/2024 Product Code22102
Lot NumberSPECS Certificate TypeCertificate of Analysis Date15/10/2024 Product Code22102
Lot NumberZH390421 Certificate TypeCertificate of Analysis Date13/08/2024 Product Code22102
Lot NumberYK352042 Certificate TypeCertificate of Analysis Date25/01/2024 Product Code22102

For Research Use Only. Not for use in diagnostic procedures.

Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title
Thermo Scientific™ SM(PEG)2 (PEGylated SMCC crosslinker) >

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Thank You! Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.