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SKI II, Tocris Bioscience™
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Artikelnummer. 18045192
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Artikelnummer. Mængde
18045192 50 mg
18024882 10 mg
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Artikelnummer. 18045192 Leverandør Tocris Bioscience Leverandørnr. 2097/50

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Beskrivelse

Selective non-lipid inhibitor of sphingosine kinase

Selective non-lipid inhibitor of sphingosine kinase (IC50 = 0.5 μM); does not act at ATP-binding site. Displays no inhibition of ERK2, PI 3-kinase, or PKCα at concentrations up to 60 μM. Reduces levels of sphingosine-1-phosphate in MDA-MB-231 breast cancer cells. Induces apoptosis and inhibits proliferation in several other tumor cell lines in vitro (IC50 = 0.9 - 4.6 μM).
TRUSTED_SUSTAINABILITY

Kemiske identifikatorer

CAS 312636-16-1
Molekylær formel C15H11ClN2OS
Molekylvægt (g/mol) 302.776
InChI nøgle ZFGXZJKLOFCECI-UHFFFAOYSA-N
Synonym ski ii, 4-4-4-chlorophenyl-2-thiazolyl amino phenol, skiii, sphk-i2, 4-4-4-chlorophenyl-1,3-thiazol-2-yl amino phenol, sphingosine kinase inhibitor 2, 4-4-4-chlorophenyl thiazol-2-ylamino phenol, phenol, 4-4-4-chlorophenyl-2-thiazolyl amino, 3vzd
PubChem CID 753704
IUPAC navn 4-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]amino]phenol
SMIL C1=CC(=CC=C1C2=CSC(=N2)NC3=CC=C(C=C3)O)Cl

Tekniske data

Kemisk navn eller materiale SKI II
Mængde 50 mg
Formel vægt 302.78
Procent renhed >98%
Produkttitel
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