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Tocris Bioscience™ SK 575
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Artikelnummer. 18788436
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Mængde:
5 mg
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18788436 5 mg
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Artikelnummer. 18788436 Leverandør Tocris Bioscience™ Leverandørnr. 7583/5

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Descrizione

Potent PARP1 Degrader (PROTAC™)

SK 575 is a potent PARP1 Degrader (PROTAC®; DC50 ≤ 6.72 nM, >99% PARP1 degradation at 10 nM). It comprises the PARP1/2 inhibitor Olaparib (Cat. No. 7579), joined by a linker to cereblon/cullin 4A ligand Thalidomide (Cat. No. 0652). SK 575 inhibits the growth of various cancer cell lines bearing BRCA1/2 mutations with IC50 values in the nanomolar range. It effectively reduces PARP1 protein levels in mouse SW620 tumor xenograft models. SK 575 dose-dependently potentiates the antitumor activity of Temozolomide (Cat. No. 2706) and Cisplatin (Cat. No. 2251) in vivo.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

TRUSTED_SUSTAINABILITY

Specifica

Kemisk navn eller materiale N-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-12-(4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1-yl)-12-oxododecanamide
CAS 2523016-96-6
Mængde 5 mg
Mål PARP
Molekylær formel C47H53FN8O8
Renhed 0.98
Titolo del prodotto
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