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Tocris Bioscience™ SJF 0628
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Artikelnummer. 18735396
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Mængde:
5 mg
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Artikelnummer. Mængde
18735396 5 mg
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Artikelnummer. 18735396 Leverandør Tocris Bioscience™ Leverandørnr. 7463/5

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Beskrivelse

Potent BRAF PROTAC™

SJF 0628 is a potent, high affinity and mutant-selective Degrader (PROTAC™) of BRAF, comprising a ligand for the von Hippel Lindau E3 ligase joined by a piperazine linker to the BRAF kinase inhibitor vemurafenib. SJF 0628 induces degradation of all 3 classes of BRAF mutant in BRAF-dependent cancer cells without inducing degradation of the BRAFWT protein. The product degrades mutant BRAFV600E in BRAF-driven cancer cell lines (DC50 = 6.8 nM - 28 nM). SJ 0628 inhibits phosphorylation of MEK and ERK in SK-MEL-28 cells (DC50 = 10 nM) and inhibits cell growth in mutant-BRAF driven cancer cells (EC50 = 37 nM).

SJF 0661 negative control (Cat. No. 7464) also available.

PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.

TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale (2 S,4 R)-1-(-2-(2-(4-(4-(3-(2,6-Difluoro-3-(propylsulfonamido)benzoyl)-1 H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
CAS 2413035-41-1
Mængde 5 mg
Mål Active Degraders
Molekylær formel C51H57F2N9O7S2
Renhed 0.98
Produkttitel
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