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Invitrogen™ SIK1 Recombinant Human Protein

SIK1 is a protein kinase that is involved in regulating AMPK-related kinases. This recombinant human SIK1 (1-303) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Brand:  Invitrogen™ PV6446

Additional Details : Weight : 0.01000kg

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Product Code. 15479053

  • 9030.00 DKK / 100µg


Estimated Shipment
07-10-2020
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Description

Description

  • Validated in LanthaScreen™ Kinase Binding Assay
  • Protocols available for simple use and optimized performance

SIK1 may mediate the physiological effects of LKB1, including its tumour suppressor function. SIK1 is also involved in signaling by various proteins like STRAD, NUAK1, NUAK2, BRSK1, BRSK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4, and MELK that are related to AMPK. Activation of SIK1 by phosphorylation on thr322 can lead to an increase in the catalytic activity of sodium/potassium ATPase alpha subunit at the plasma membrane. This results in an increase in intracellular sodium in intact mammalian cells.

Specifications

Specifications

NP_173354
Serine/Threonine Kinase
Recombinant, Active, Catalytic
Human
150094
100μg
aa 1-303
Storage Buffer: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.1 mM PMSF, 0.25 mM DTT, 25% glycerol

Store at -68 to -85°C. After first use, aliquot and store to avoid multiple freeze-thaws.
Baculovirus
Drug Development, Signal Transduction
Kinase Assay
61 kDa
SNF1LK, MSK, SIK1
GST Tag
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