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Invitrogen™ SIK1 Recombinant Human Protein

SIK1 is a protein kinase that is involved in regulating AMPK-related kinases. This recombinant human SIK1 (1-303) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Brand:  Invitrogen™ PV6445

Additional Details : Weight : 0.01000kg

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Product Code. 15469053

  • 2450.00 DKK / 10µg


Estimated Shipment date
from Supplier 01-03-2018
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Description

Description

  • Validated in LanthaScreen™ Kinase Binding Assay
  • Protocols available for simple use and optimized performance

SIK1 may mediate the physiological effects of LKB1, including its tumour suppressor function. SIK1 is also involved in signaling by various proteins like STRAD, NUAK1, NUAK2, BRSK1, BRSK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4, and MELK that are related to AMPK. Activation of SIK1 by phosphorylation on thr322 can lead to an increase in the catalytic activity of sodium/potassium ATPase alpha subunit at the plasma membrane. This results in an increase in intracellular sodium in intact mammalian cells.

Specifications

Specifications

NP_173354
50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
61kDa
Store at -68 to -85°C. After first use, aliquot and store to avoid multiple freeze-thaws.
SNF1LK, MSK, SIK1
Baculovirus
Human
GST Tag
Target & Lead Identification & Validation|Kinase Biology|Biochemical Kinase Assays|Industrial & Applied Science|Pharma & Biopharma
150094
10μg
Catalytic, Recombinant, Active
Kinase Assay
aa 1-303
Yes
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