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Tocris Bioscience™ SEN 177
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Artikelnummer. 18758736
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18758736 10 mg
18776296 50 mg
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Artikelnummer. 18758736 Leverandør Tocris Bioscience™ Leverandørnr. 6979/10

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Beskrivelse

Potent glutaminyl cyclase inhibitor; disrupts binding of SIRP-α to CD47

SEN 177 is a potent glutaminyl cyclase (QPCT) inhibitor (IC50 = 53 nM). SEN 177 reduces aggregation of mutant huntingtin (mHTT) through inhibition of QPCT and reduces Q80 aggregates in vitro. Inhibition of QPCT also reduces aggregate formation in in vivo models of Huntington's disease. SEN 177 potently inhibits QPCT-like protein (IC50 = 13 nM) and disrupts binding of SIRP-α to CD47. The compound increases antibody-dependent cellular phagocytosis and cytotoxicity in cancer cell lines.
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Tekniske data

Kemisk navn eller materiale 6 '-Fluoro-2-[4-(4-methyl-4 H-1,2,4-triazol-3-yl)-1-piperidinyl]-3,3 '-bipyridine
CAS 2117405-13-5
Mængde 10 mg
Mål Other Transferase Inhibitors
Molekylær formel C18H19FN6
Renhed 0.98
Produkttitel
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