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Tocris Bioscience™ Selinexor
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Artikelnummer. 18737176
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Mængde:
10 mg
50 mg
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Artikelnummer. Mængde
18737176 10 mg
18736116 50 mg
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Artikelnummer. 18737176 Leverandør Tocris Bioscience™ Leverandørnr. 7760/10

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1563.44 DKK valid until 2026-05-31
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Beskrivelse

Selective exportin 1 (XPO1/CRM1) inhibitor

Selinexor is an inhibitor of the exportin 1 (XPO1/CRM1) nuclear exporter. Shows selectivity for TNBC over ER-positive breast cancer cell lines (IC50 values are 11-550 nM and >1000 nM, respectively), and reduces growth of xenografts. Inhibits growth of thyroid cancer cell lines (IC50 = 150-500 nM), potentiates the anti-tumor effects of Olaparib (Cat. No. 7579) in ovarian cancer and breast cancer. Also a potent inhibitor of SARS-CoV-2 replication in vitro (EC50 = 10 nM) and downregulates the production of pro-inflammatory cytokines including TNF-α and IL-6.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale (2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyrazinyl)hydrazide
CAS 1393477-72-9
Mængde 10 mg
Mål Antiviral Compounds
Molekylær formel C17H11F6N7O
Produkttitel
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