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STEMCELL Technologies SCR7

Artikelnummer. 17190322
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10 mg
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Artikelnummer. Mængde
17190322 5 mg
17100332 10 mg
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Artikelnummer. 17190322 Leverandør STEMCELL Technologies Leverandørnr. 74102

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Beskrivelse

NHEJ pathway inhibitor; inhibits DNA ligase IV

  • SCR7 is an inhibitor of DNA ligase IV, which is responsible for the repair of DNA double-strandbreaks via the non-homologous end joining (NHEJ) repair pathway (Srivastava et al.) Due to its reported success in impeding cancer cell growth and potential impact on future cancer therapeutics, SCR7 has been closely studied in many recent publications (Hosoya & Miyagawa; John et al.)
  • Inhibits NHEJ-dependent DNA repair; this inhibition is reported to enhance precise homology-directed repair (HDR)-dependent CRISPR-Cas9 genome editing (Chu et al.; Maruyama et al.; Pinder et al.) However, these effects are cell type-specific and context-dependent (Song et al.; Xie et al.; Yang et al.; Zhang et al.)
  • Activates apoptosis of cancer cells by inhibiting DNA ligase IV to increase the efficacy of DNA double-strand break-inducing therapy (chemo- or radio-therapy) (Srivastava et al.)

Tekniske data

CAS 1533426-72-0
Mængde 5 mg
Molekylær formel C18H14N4OS
Renhed ≥95%
Produkttitel
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