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Tocris Bioscience™ SAG dihydrochloride

Artikelnummer. 18053842
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10 mg
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18053842 10 mg
18783999 1 mg
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Artikelnummer. 18053842 Leverandør Tocris Bioscience™ Leverandørnr. 6390/10

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Beskrivelse

Dihydrochloride salt of SAG; Smo receptor agonist

SAG dihydrochloride is a water-soluble dihydrochloride salt of SAG (Cat. No. 4366). SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM); antagonizes Cyclopamine (Cat. No. 1623) action at the Smo receptor. SAG potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50 ∼ 3 nM) and induces pathway activation independently of Ptch proteins. SAG is a putative inhibitor of a cellular component required for Hedgehog signaling and also enhances neuronal differentiation of iPSCs into dopaminergic neurons.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale 3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide dihydrochloride
CAS 2702366-44-5
Analyseprocentområde >99%
Mængde 10 mg
Molekylær formel C28H28ClN3OS0.2 HCl
Formel vægt Observed MW: 562.98
Renhed 98%
Produkttitel
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