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(S,R,S)-AHPC hydrochloride, MedChemExpress

Artikelnummer. 16480899
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100 mg
500 mg
1 g
5 g
Pakningsstørrelse:
500mg
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16474666 100 mg -
16441536 500 mg 500mg
16406287 5 g -
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Artikelnummer. 16480899 Leverandør Medchem Express Leverandørnr. HY101763A

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Beskrivelse

MedChemExpress (S,R,S)-AHPC hydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC hydrochloride can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells.

(S,R,S)-AHPC hydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC hydrochloride can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells.

Tekniske data

Kemisk navn eller materiale (S,R,S)-AHPC hydrochloride
CAS 1448189-80-7
Farve White
Renhedsgrad noter Research
Molekylær formel C22H31ClN4O3S
Mængde 1 g
Synonym VH032-NH2 hydrochlorideVHL ligand 1 hydrochloride
Opløselighedsinformation DMSO : 250 mg/mL (535.31 mM; Need ultrasonic) ∣H2O : 100 mg/mL (214.12 mM; Need ultrasonic)
SMIL O=C([C@H](C[C@@H](O)C1)N1C([C@@H](N)C(C)(C)C)=O)NCC2=CC=C(C(SC=N3)=C3C)C=C2.Cl
Molekylvægt (g/mol) 467.02
Formel vægt 467.02
Procent renhed 95.05%
Grad Research
Fysisk form Powder
Til brug med (applikation) Cancer-programmed cell death
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Research purposes only

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