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STEMCELL Technologies (S)-MG132

Artikelnummer. 17170192
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10 mg
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17170192 1 mg
17180192 10 mg
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Artikelnummer. 17170192 Leverandør STEMCELL Technologies Leverandørnr. 73262

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Beskrivelse

Ubiquitin-proteasome and NF-κB pathway inhibitor; Inhibits proteasome and stabilizes IκB

  • (S)-MG132 is a reversible, cell-permeable inhibitor of proteasome activity (IC50 = 100 nM; Kisselev & Goldberg) and calpain (IC50 = 1.2 μM; Tsubuki et al.) The ubiquitin-proteasome pathway selectively degrades intracellular proteins, thereby clearing damaged or misfolded proteins, and regulating the availability of key proteins involved in the control of inflammatory processes and cell cycle regulation
  • (S)-MG132 suppresses NF-κB activation by preventing IκB degradation (IC50 = 3 μM; Arlt et al.), Palombella et al.), Ortiz-Lazareno et al.)
  • Blocks apoptosis triggered by DNA damage in HeLa cells (Zhang et al.)
  • Inhibits NF-κB activation, sensitizing a variety of carcinoma cell lines to apoptosis (Arlt et al.)
  • Cytotoxic effects on a variety of human cancer cell lines (Banerjee & Liefshitz)
  • Inhibits growth of mouse melanoma (B16) and human ocular melanoma (IPC227F) cell lines (Vivier et al.)

Tekniske data

CAS 133407-82-6
Synonym Z-Leu-Leu-Leu-CHO; Calpain inhibitor IV-2
Mængde 1 mg
Molekylær formel C26H41N3O5
Renhed ≥98%
Produkttitel
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