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STEMCELL Technologies Ruxolitinib​

Artikelnummer. 17190212
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10 mg
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17190212 1 mg
17100222 10 mg
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Artikelnummer. 17190212 Leverandør STEMCELL Technologies Leverandørnr. 73402

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Beskrivelse

JAK/STAT pathway inhibitor; Inhibits JAK1 and JAK2

  • Ruxolitinib is an ATP mimic that inhibits all Janus-associated kinase (JAK) family kinases with a preference for JAK-1 and JAK-2 over JAK-3 and TYK2 with IC50 values of 3.3, 2.8, 428 and 19 nM respectively (Verstovsek; Quintás-Cardama et al.)
  • Suppresses erythroid progenitor colony formation from peripheral blood mononuclear cells of polycythemia vera patients with the constitutively active JAK2 V617F mutation
  • Reduces malignant cell proliferation and decreases interleukin-6 and TNF-α signaling in a JAK2 V617F-driven mouse model of myeloproliferative disorder (Quintás-Cardama et al.)
  • Promotes hair regrowth in a mouse model of alopecia areata (Xing et al.)

Tekniske data

CAS 941678-49-5
Synonym INCB 018424, INC 424
Mængde 1 mg
Molekylær formel C17H18N6
Renhed ≥98%
Produkttitel
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