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STEMCELL Technologies Rolipram

Artikelnummer. 17160212
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Mængde:
5 mg
25 mg
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Artikelnummer. Mængde
17160212 5 mg
17170212 25 mg
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Artikelnummer. 17160212 Leverandør STEMCELL Technologies Leverandørnr. 73382

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Beskrivelse

cAMP pathway activator; Inhibits type 4 cyclic nucleotide phosphodiesterases (PDE4)

  • Rolipram is a cell-permeable, selective inhibitor of Type 4 cyclic nucleotide phosphodiesterases (PDE4), which mediate cyclic AMP (cAMP) degradation
  • Rolipram preferably inhibits PDE4 isoform A (IC50 = 3 nM) over other isoforms such as B and D (IC50 = 130 and 240 nM respectively; MacKenzie & Houslay)
  • It inhibits interferon (IFN)-γ stimulated phosphorylation of p38 mitogen-activated protein (MAP) kinase through PDE4B and/or PDE4D isoform inhibition (MacKenzie & Houslay)

Tekniske data

CAS 61413-54-5
Synonym SB 95952; ZK 62711
Mængde 5 mg
Molekylær formel C16H21NO3
Renhed ≥98%
Produkttitel
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