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Beskrivelse
This polyclonal antibody reacts specifically with the human Rab11A protein. Cross-reactivity with other Rab family members has not been detected. Positive control: Human HEK-293 cells.
Rab11A is a member of the YPT-1 subfamily of Ras-related GTP-binding proteins. Rab11A mRNA has been detected in a variety of tissues including brain, testis, spleen, heart, and gastrointestinal mucosa. In the gastric fundus the Rab11A protein is expressed in parietal cell tubulovesicles membranes. Expression of the Rab11A protein appears to occur in discrete epithelial cell populations where it localizes to apical vesicular populations. Recent studies have shown Rab11A is essential for resecretion of alpha-synuclein out of neuronal cells via endosome recycling and is required for exocytosis of discoidal/fusiform vesicles of bladder umbrella cells. Rab11A is also implicated in biogenesis of Birbeck granules and endosomal activation of the PI3K/AKT signaling pathway via G beta gamma trafficking.
Tekniske data
| RAB11A | |
| Polyclonal | |
| Unconjugated | |
| RAB11A | |
| 24KG; RAB 11A, member oncogene family; RAB11; rab-11; rab11 GTP-binding protein; Rab11a; RAB11a, member RAS oncogene family; ras-related protein Rab-11A; tubulovesicle-associated protein; YL8 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 100009072, 403957, 53869, 81830, 8766 | |
| -20°C | |
| Liquid | |
| HM 505 Cryostat |
| ELISA, Immunohistochemistry (Paraffin), Immunomicroscopy, Immunoprecipitation, Western Blot, Immunocytochemistry | |
| 0.25 mg/mL | |
| PBS with 0.1% sodium azide; pH 7.4 | |
| P62490, P62491, P62492, P62493, P62494 | |
| RAB11A | |
| Synthetic peptide derived from the C-terminal hypervariable region of the human Rab11a sequence. This peptide shares 10 of 17 residues with the related Rab11b protein. | |
| 100 μg | |
| Primary | |
| Human, Mouse, Rat, Canine, Rabbit, Monkey | |
| Antibody | |
| IgG |
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