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Tocris Bioscience™ TC-G 1008
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Artikelnummer. 18730528
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50 mg
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18730528 50 mg
18704519 10 mg
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Artikelnummer. 18730528 Leverandør Tocris Bioscience™ Leverandørnr. 5355/50

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Beskrivelse

Potent and selective GPR39 agonist

Potent and selective GPR39 agonist (EC50 values are 0.4 and 0.8 nM for rat and human receptors respectively). Selective over a panel of kinases (IC50s > 10 μM) and displays minimal binding affinity for ghrelin and neurotensin-1 receptors (IC50s > 30 μM). Increases GLP-1 levels in vitro and in vivo. Reduces TNF-α-induced oxidative stress, mitochondrial dysfunction, cytokine expression and secretion of MMPs in fibroblast-like synoviocytes (FLS). Orally bioavailable.

TC-G 1008 is a potent and selective GPR39 agonist (EC50 values are 0.4 and 0.8 nM for rat and human receptors respectively). Selective over a panel of kinases (IC50s > 10 μM) and displays minimal binding affinity for ghrelin and neurotensin-1 receptors (IC50s > 30 μM). Increases GLP-1 levels in vitro and in vivo. Reduces TNF-α-induced oxidative stress, mitochondrial dysfunction, cytokine expression and secretion of MMPs in fibroblast-like synoviocytes (FLS). Orally bioavailable.
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Tekniske data

Kemisk navn eller materiale TC-G 1008
CAS 1621175-65-2
Synonym N-[3-Chloro-4-[[[2-(methylamino)-6-(2-pyridinyl)-4-pyrimidinyl]amino]methyl]phenyl]methanesulfonate
Mængde 50 mg
Opløselighed Soluble to 20mM in DMSO
Molekylær formel C18H19ClN6O2S
Formel vægt 418.9
Fysisk form Solid
Produkttype Bioactive Small Molecule
Renhed >98%

Research Use Only. Not For Human or Veterinary Use

Produkttitel
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