missing translation for 'onlineSavingsMsg'
Få mere at vide
Få mere at vide
Tocris Bioscience™ TC-G 1008
Klik for at se tilgængelige muligheder
Mængde:
10 mg
50 mg
Beskrivelse
Potent and selective GPR39 agonist (EC50 values are 0.4 and 0.8 nM for rat and human receptors respectively). Selective over a panel of kinases (IC50s > 10 μM) and displays minimal binding affinity for ghrelin and neurotensin-1 receptors (IC50s > 30 μM). Increases GLP-1 levels in vitro and in vivo. Reduces TNF-α-induced oxidative stress, mitochondrial dysfunction, cytokine expression and secretion of MMPs in fibroblast-like synoviocytes (FLS). Orally bioavailable.
TC-G 1008 is a potent and selective GPR39 agonist (EC50 values are 0.4 and 0.8 nM for rat and human receptors respectively). Selective over a panel of kinases (IC50s > 10 μM) and displays minimal binding affinity for ghrelin and neurotensin-1 receptors (IC50s > 30 μM). Increases GLP-1 levels in vitro and in vivo. Reduces TNF-α-induced oxidative stress, mitochondrial dysfunction, cytokine expression and secretion of MMPs in fibroblast-like synoviocytes (FLS). Orally bioavailable.
Tekniske data
Tekniske data
| Kemisk navn eller materiale | TC-G 1008 |
| CAS | 1621175-65-2 |
| Synonym | N-[3-Chloro-4-[[[2-(methylamino)-6-(2-pyridinyl)-4-pyrimidinyl]amino]methyl]phenyl]methanesulfonate |
| Mængde | 50 mg |
| Opløselighed | Soluble to 20mM in DMSO |
| Molekylær formel | C18H19ClN6O2S |
| Formel vægt | 418.9 |
| Fysisk form | Solid |
| Produkttype | Bioactive Small Molecule |
| Renhed | >98% |
Research Use Only. Not For Human or Veterinary Use
Korrektion af produktindhold
Dit input er vigtigt for os. Udfyld denne formular for at give feedback relateret til indholdet på dette produkt.
Produkttitel
Ser du en mulighed for forbedring?Del en indholdskorrektion