missing translation for 'onlineSavingsMsg'
Få mere at vide
  1. Home
  2. Products
  3. Proteinanalysereagenser
  4. Bioaktive små molekyler
  5. Tocris Bioscience™ JTE 607 Dihydrochloride

Tocris Bioscience™ JTE 607 Dihydrochloride
GREENER_CHOICE

Artikelnummer. 18766658
Skift visning
Klik for at se tilgængelige muligheder
Mængde:
10 mg
50 mg
2 product options available for selection
Product selection table with 2 available options. Use arrow keys to navigate and Enter or Space to select.
Artikelnummer. Mængde
18766658 50 mg
18733939 10 mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 2 options available.
2 options
Denne vare kan ikke returneres. Se returpolicy
Artikelnummer. 18766658 Leverandør Tocris Bioscience™ Leverandørnr. 5185/50

Please to purchase this item. Need a web account? Register with us today!

Denne vare kan ikke returneres. Se returpolicy

Beskrivelse

Cytokine release inhibitor; anti-inflammatory

JTE 607 dihydrochloride is a pro-drug that is cleaved by carboxylesterase 1 (CES1) to its active metabolite, which then binds to cleavage and polyadenylation specificity factor 3 (CPSF3; Kd = 370 nM at human CPSF3). Treatment of A-673 cells with JTE 607 results in inhibition of mRNA cleavage and accumulation of nuclear R-loops. JTE 607 induces apoptosis in leukemia cells in vitro and prolongs survival in a mouse leukemia model. JTE 607 inhibits cytokine release and inhibits production of IL-1β, IL-8, IL-6, IL-10 and TNFα (IC50 values are 5.9, 7.3, 8.8, 9.1 and 11.0 nM, respectively) from LPS-stimulated PBMCs. In a rat model of lung injury, JTE 607 reduces proinflammatory cytokine-release and attenuates lung permeability.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale JTE 607 dihydrochloride
CAS 188791-09-5
Synonym N-[3,5-Dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride
Mængde 50 mg
Opløselighed Soluble to 100mM in water and to 100mM in DMSO
Molekylær formel C25H31Cl2N3O5·2HCl
Formel vægt 597.36
Fysisk form Solid
Produkttype Bioactive Small Molecule
Renhed >98%

Research Use Only. Not For Human or Veterinary Use

Produkttitel
Vælg et problem

Ved at klikke på Send, anerkender du, at du kan blive kontaktet af Fisher Scientific med hensyn til den feedback, du har givet i denne formular. Vi deler ikke dine oplysninger til andre formål. Alle angivne kontaktoplysninger skal også vedligeholdes i overensstemmelse med vores Privatlivspolitik.