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Tocris Bioscience™ EPZ 004777
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Artikelnummer. 18708588
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Mængde:
10 mg
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Artikelnummer. Mængde
18708588 10 mg
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Artikelnummer. 18708588 Leverandør Tocris Bioscience™ Leverandørnr. 5567/10

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Beskrivelse

Highly potent DOT1L inhibitor

EPZ 004777 is a highly potent DOT1L inhibitor (IC50 = 0.4 nM). Exhibits >1000-fold selectivity for DOT1L over a panel of other methyltransferases. Selectively inhibits proliferation and induces apoptosis of MLL-rearranged cells in vitro. Prolongs survival in a MLL xenograft mouse model. Enhances efficiency of Yamanaka-factor factor reprogramming of fibroblasts by 3-4-fold.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale EPZ 004777
CAS 1338466-77-5
Synonym 7-[5-Deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Mængde 10 mg
Opløselighed Soluble to 100mM in DMSO and to 100mM in ethanol
Molekylær formel C28H41N7O4
Formel vægt 539.67
Fysisk form Solid
Produkttype Bioactive Small Molecule
Renhed >98%

Research Use Only. Not For Human or Veterinary Use

Produkttitel
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