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Tocris Bioscience™ EPZ 004777
Highly potent DOT1L inhibitor
Brand: Tocris Bioscience™ 5567/10
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Beskrivelse
EPZ 004777 is a highly potent DOT1L inhibitor (IC50 = 0.4 nM). Exhibits >1000-fold selectivity for DOT1L over a panel of other methyltransferases. Selectively inhibits proliferation and induces apoptosis of MLL-rearranged cells in vitro. Prolongs survival in a MLL xenograft mouse model. Enhances efficiency of Yamanaka-factor factor reprogramming of fibroblasts by 3-4-fold.Tekniske data
| EPZ 004777 | |
| 7-[5-Deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine | |
| Soluble to 100mM in DMSO and to 100mM in ethanol | |
| Bioactive Small Molecule |
| 1338466-77-5 | |
| 10 mg | |
| Solid |
Produkttitel
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